Antimicrobial Resistance Surveillance in Tertiary Care: A Two-Year Retrospective Audit
Department of Clinical Microbiology, Tertiary Care Teaching Hospital, Kolkata, West Bengal, India
Corresponding Author: Roy N, Doctus Journal of Microbiology & Immunology.
Abstract
We audited 18,942 clinical isolates processed over 24 months in a tertiary referral laboratory to describe resistance trends and their relationship to prescribing. Escherichia coli and Klebsiella pneumoniae together accounted for 41% of Gram-negative isolates, with extended-spectrum beta-lactamase production in 58% and 63% respectively. Carbapenem resistance in Klebsiella rose from 19% to 27% across the audit period, tracking a parallel rise in empirical carbapenem use in the critical care units. Methicillin resistance in Staphylococcus aureus remained stable at approximately 34%. The data support a unit-level antibiotic stewardship intervention targeted at empirical carbapenem prescribing rather than a hospital-wide restriction policy.
Keywords
Antimicrobial Resistance; Surveillance; ESBL; Carbapenem Resistance; Antibiotic Stewardship; Retrospective Audit
How to Cite
Roy N, Islam R and Ghosh K. “Antimicrobial Resistance Surveillance in Tertiary Care: A Two-Year Retrospective Audit”. Doctus Journal of Microbiology & Immunology 1.2 (2026): 33-47.
Copyright and Licence
© 2026 Roy N. This is an open access article distributed under the Creative Commons Attribution Licence, which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.