Comparative Efficacy of Fixed-Dose Combinations in Newly Diagnosed Hypertension
Department of Pharmacology and Department of General Medicine, Medical College and Hospital, Kolkata, West Bengal, India
Corresponding Author: Chatterjee S, Doctus Journal of Pharmacology.
Abstract
Fixed-dose combinations are widely prescribed at hypertension diagnosis, but head-to-head data in South Asian populations remain sparse. In this open-label comparative study, 268 treatment-naive adults with stage 1 or 2 hypertension were allocated to one of three fixed-dose combinations and followed for 12 weeks. All three arms achieved significant reductions in mean ambulatory systolic pressure. The amlodipine-telmisartan arm produced the largest reduction and the highest proportion reaching target, while the diuretic-containing arm showed the greatest variability and the most treatment-limiting adverse events, chiefly hypokalaemia and cramps. Adherence, measured by pill count, exceeded 90% in all arms, supporting the single-pill strategy irrespective of the combination selected.
Keywords
Hypertension; Fixed-Dose Combination; Antihypertensive; Adherence; Ambulatory Blood Pressure; Comparative Study
How to Cite
Chatterjee S, Kundu A, Rahman M and Sen B. “Comparative Efficacy of Fixed-Dose Combinations in Newly Diagnosed Hypertension”. Doctus Journal of Pharmacology 2.9 (2026): 88-101.
Copyright and Licence
© 2026 Chatterjee S. This is an open access article distributed under the Creative Commons Attribution Licence, which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.