Zinc Supplementation and Prostate Carcinoma Risk: A Meta-Analysis
Department of Medical Oncology and Department of Preventive Oncology, Cancer Centre, Kolkata, West Bengal, India
Corresponding Author: Ghosh K, Doctus Journal of Oncology.
Abstract
Reported associations between dietary and supplemental zinc and prostate carcinoma have been inconsistent across cohorts. We meta-analysed 27 observational studies comprising 51,340 men, stratifying by supplement dose, duration and baseline dietary intake. Pooled analysis showed no overall association between habitual zinc supplementation and prostate carcinoma incidence. A dose-response signal appeared only at intakes exceeding 100 mg per day sustained beyond ten years, where risk estimates rose modestly, though the contributing studies were few and residual confounding by health-seeking behaviour is likely. Zinc intake within recommended limits shows no measurable effect on risk, and high-dose long-term supplementation cannot be recommended for chemoprevention.
Keywords
Zinc; Prostate Carcinoma; Meta-Analysis; Chemoprevention; Dose-Response; Dietary Supplements
How to Cite
Ghosh K, Roy N and Kundu A. “Zinc Supplementation and Prostate Carcinoma Risk: A Meta-Analysis”. Doctus Journal of Oncology 1.3 (2026): 61-78.
Copyright and Licence
© 2026 Ghosh K. This is an open access article distributed under the Creative Commons Attribution Licence, which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.